Vinnie & Spike are noticeably faster while moving on air, rather than on land. Players are encouraged to keep flying instead of walking.
Spike Dive starts off pretty weak early game. Use it to farm Solar, poke enemies or as an escape tool. With some upgrades, it becomes more effective at killing enemies.
If you are using Bag Full of Gold Fish, it might be a good idea to play more passively and focus on farming whenever you drop below the required Solar limit. Once you have enough Solar again, you can go back to ganks and pushes.
Aiming downwards with Spike Dive while close to the ground is an effective way of landing both spike explosions from Dead Seahorse Head on the same target.
Remember that if you use Spike Dive to attack your enemies, you won't have it available for an escape. Smoke Screen (and any upgrades it may have) can assist you in your escape.
Using Sharky & Remora can help you stay at a safe distance from your enemy while attacking or to get kills that wouldn't be possible otherwise. This upgrade also allows Vinnie & Spike to outrange turrets, making them great at pushing, specially when combined with Smoke Screen which stops droids from attacking, giving you time to kill them while destroying the turret.
Although Bubble Gun deals fairly low damage early on, it pierces through enemies, making it a good droid farming tool.
When using The Godfish upgrade, keep in mind that you will glow when you are near an enemy with 150 or more Solar even if he's inside a hide area or invisible. Use this as a "radar" and be prepared to attack or flee accordingly.
Vinnie & Spike have poor acceleration when falling, specially inside the anti-gravity lift on AI Station 404, making it easier to land abilities on them during that time.
Vinnie & Spike have no access to traditional regeneration in form of Med-i'-can. Try harrassing them early on, forcing them to go after healthpacks, creeps or to retreat.
Unlike Froggy G, Vinnie & Spike are vulnerable to damage during Spike Dive. Attack them when they use it offensively.
If Vinnie & Spike are using Rubber Mask paired with Solar Krab Burgers, do your best to step out of Smoke Screen as soon as possible, as you'll be healing them more and more the longer you stay inside of it.
Remember: Blinding effects do not disable your minimap. Use it to keep track of Vinnie & Spike's position.